Description :

Drug resistance remains one of the biggest challenges in cancer therapy it exists across all types of cancer and all modes of treatment including molecularly targeted therapy immunotherapy and chemotherapy. Cancer drug resistance one of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells this is a very serious problem that may lead to recurrence of disease or even death this section is intended to introduce some of the main ways in which cancer cells can resist treatments. Drug resistance in cancer is a well known phenomenon that results when cancer becomes tolerant to pharmaceutical treatment resistance to anticancer drugs arises from a wide variety of factors such as genetic mutations and or epigenetic changes conserved but upregulated drug efflux and various other cellular and molecular mechanisms. The cover for issue 1 of oncotarget features figure 2 results in clinical trials published in drug resistant cells with very large proliferative potential grow exponentially in metastatic